Administration of M. leprae Hsp65 Interferes with the Murine Lupus Progression
| Autor: | Antonio C.M. Camargo, Denise V. Tambourgi, Eliana Blini Marengo, Fernanda C. V. Portaro, Osvaldo A. Sant'Anna, Luciana Vieira de Moraes, Luciana Vieira Carvalho, Luiz Vicente Rizzo, Beatriz L. Fernandes, Marcella Faria |
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| Rok vydání: | 2008 |
| Předmět: |
Chaperonins
Immunology/Immunomodulation lcsh:Medicine Immunology/Autoimmunity medicine.disease_cause Biochemistry Autoimmunity Pathogenesis Mice Glomerulonephritis Immune system Bacterial Proteins Heat shock protein medicine Animals Lupus Erythematosus Systemic lcsh:Science Pharmacology Evolutionary Biology Multidisciplinary Lupus erythematosus Dose-Response Relationship Drug biology lcsh:R Wild type Chaperonin 60 DNA medicine.disease Molecular biology Mycobacterium leprae Disease Models Animal Apoptosis Antibody Formation Immunology/Immune Response Disease Progression biology.protein lcsh:Q Antibody Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 3, Iss 8, p e3025 (2008) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0003025 |
| Popis: | The heat shock protein [Hsp] family guides several steps during protein synthesis, are abundant in prokaryotic and eukaryotic cells, and are highly conserved during evolution. The Hsp60 family is involved in assembly and transport of proteins, and is expressed at very high levels during autoimmunity or autoinflammatory phenomena. Here, the pathophysiological role of the wild type [WT] and the point mutated K(409)A recombinant Hsp65 of M. leprae in an animal model of Systemic Lupus Erythematosus [SLE] was evaluated in vivo using the genetically homogeneous [NZBxNZW]F(1) mice. Anti-DNA and anti-Hsp65 antibodies responsiveness was individually measured during the animal's life span, and the mean survival time [MST] was determined. The treatment with WT abbreviates the MST in 46%, when compared to non-treated mice [p |
| Databáze: | OpenAIRE |
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