Effects of antibiotics on degradation and bioavailability of different vitamin E forms in mice
| Autor: | Chung S. Yang, Anna B. Liu, Mao-Jung Lee, Ping Xie, Yong Lin, Linwu Ran |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Clinical Biochemistry Antibiotics Tocopherols Urine Gut flora Biochemistry 03 medical and health sciences Mice 0302 clinical medicine Internal medicine medicine Animals Vitamin E Feces Morning Kidney biology business.industry Tocotrienols General Medicine biology.organism_classification Bioavailability Anti-Bacterial Agents Gastrointestinal Microbiome Mice Inbred C57BL 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Molecular Medicine business |
| Zdroj: | BioFactors (Oxford, England). 45(3) |
| ISSN: | 1872-8081 |
| Popis: | Tocopherols (T) and tocotrienols (T3), all existing in α, β, γ, and δ-forms, are the eight forms of vitamin E (VE). In this study, we investigated the effects of gut microbiota on the degradation and tissue levels of different VE forms by treating mice with antibiotics in drinking water for 12 days. The mice also received an intragastric (i.g.) dose of VE mixture (mVE; α-T, γ-T, δ-T, γ-T3, and δ-T3, each at a dose of 75 mg/kg) every morning. Antibiotic treatment significantly increased the blood levels of all VE forms in mice that received an i.g. dose of mVE in the morning, 3 h before sacrifice. Without this morning dose, the blood levels of α-T were at the normal physiological levels, but those of the other VE forms were much lower; and the levels of all VE forms were not significantly affected by antibiotics. The liver levels of these VE forms were generally higher and followed the same pattern as the serum. On the contrary, the levels of most side-chain degradation metabolites of VE forms in the serum, liver, kidney, urine, and fecal samples were significantly decreased by antibiotics. The increased bioavailability of VE by antibiotics is probably due to increased absorption of VE or its decreased degradation by gut microbes. The results demonstrate the important roles of gut microbiota in the degradation of VE and in decreasing the bioavailabilities of VE forms. © 2019 BioFactors, 45(3):450-462, 2019. |
| Databáze: | OpenAIRE |
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