cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice
| Autor: | Daniele G. Souza, Mauro M. Teixeira, Lirlândia P. Sousa, Celso Martins Queiroz-Junior, Larissa Froede Brito, Eliana de Faria Garcia, Diego Pinto de Oliveira, Flávio A. Amaral, Vivian Vasconcelos Costa, Nathália Vieira Batista, Fernão Castro Braga, Mariana Assíria de Oliveira, Fernanda M. Coelho, Luiza C. M. Candido, Rodrigo Maia de Pádua |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Chemokine Gout Anti-Inflammatory Agents Pharmaceutical Science Arthritis Inflammation Pharmacology Ligands Analytical Chemistry Mice chemistry.chemical_compound NF-KappaB Inhibitor alpha Aconitic acid Drug Discovery medicine Humans Animals Alismataceae Echinodorus grandiflorus biology Tumor Necrosis Factor-alpha Chemistry Aconitic Acid Organic Chemistry NF-kappa B biology.organism_classification medicine.disease Uric Acid IκBα Complementary and alternative medicine Rheumatoid arthritis biology.protein Molecular Medicine Chemokines medicine.symptom |
| Zdroj: | Planta Medica. 88:1123-1131 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/a-1676-4371 |
| Popis: | cis-Aconitic acid is a constituent from the leaves of Echinodorus grandiflorus, a medicinal plant traditionally used in Brazil to treat inflammatory conditions, including arthritic diseases. The present study aimed to investigate the anti-arthritic effect of cis-aconitic acid in murine models of antigen-induced arthritis and monosodium urate-induced gout. The possible underlying mechanisms of action was evaluated in THP-1 macrophages. Oral treatment with cis-aconitic acid (10, 30, and 90 mg/kg) reduced leukocyte accumulation in the joint cavity and C-X-C motif chemokine ligand 1 and IL-1β levels in periarticular tissue. cis-Aconitic acid treatment reduced joint inflammation in tissue sections of antigen-induced arthritis mice and these effects were associated with decreased mechanical hypernociception. Administration of cis-aconitic acid (30 mg/kg p. o.) also reduced leukocyte accumulation in the joint cavity after the injection of monosodium urate crystals. cis-Aconitic acid reduced in vitro the release of TNF-α and phosphorylation of IκBα in lipopolysaccharide-stimulated THP-1 macrophages, suggesting that inhibition of nuclear factor kappa B activation was an underlying mechanism of cis-aconitic acid-induced anti-inflammatory effects. In conclusion, cis-aconitic acid has significant anti-inflammatory effects in antigen-induced arthritis and monosodium urate-induced arthritis in mice, suggesting its potential for the treatment of inflammatory diseases of the joint in humans. Additionally, our findings suggest that this compound may contribute to the anti-inflammatory effect previously reported for E. grandiflorus extracts. |
| Databáze: | OpenAIRE |
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