Prognostic factors in 161 patients with mucosal melanoma: a study of German Central Malignant Melanoma Registry

Autor: Ulrike Keim, E. Sarac, Teresa Amaral, Ulrike Leiter, Thomas Eigentler, Claus Garbe, Andrea Forschner
Přispěvatelé: Ocak, Esra Saraç, Amaral, T., Keim, U., Leiter, U., Forschner, A., Eigentler, T. K., Garbe, C., Koç University Hospital
Rok vydání: 2020
Předmět:
Zdroj: Journal of the European Academy of Dermatology and Venereology
ISSN: 1468-3083
0926-9959
DOI: 10.1111/jdv.16306
Popis: Background: mucosal melanoma is a rare malignancy which represents approximately 1% of all melanomas. It is shown that mucosal melanomas have a different biology and less favourable prognosis than its cutaneous counterpart. Objectives: predictive and prognostic factors of survival for mucosal melanoma have not yet been elucidated. The aim of this study was to investigate risk factors affecting the course of mucosal melanoma patients followed in our clinic. Methods: one hundred and sixty-one patients with mucosal melanoma prospectively documented in the German Central Malignant Melanoma Registry (CMMR) were included in this study. Gender, age, localization, stage at first medical examination, tumour thickness and mutational status were documented. The American Joint Committee on Cancer (AJCC), 7th edition was used to define tumour stage. Kaplan-Meier survival curves were evaluated compared with the log-rank test. Multivariate Cox proportional hazard models were used to identify significant independent prognostic factors. Results: according to the localization, patients were categorized in 44.7% oral-nasal, 28.6% genital, 20.5% anorectal and 6.2% visceral. Genital mucosal melanomas had the most favourable 5-year OS rate (58.6%) followed by visceral (58.3%) and oral-nasal (39.3%). Anorectal melanomas had the worst OS time (median: 21 +/- 4.8 months) and 5-year survival rate (22.7%). Patients
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Databáze: OpenAIRE
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