Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity
Autor: | Shing-Hwa Liu, Rui-Yi Chen, Meng-Tsan Chiang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Lipolysis Adipose tissue Diet High-Fat Catalysis Article high-fat diet-fed rats Inorganic Chemistry Lipid peroxidation lcsh:Chemistry Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound high-molecular-weight chitosan Internal medicine lipid metabolism medicine Animals Obesity Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy chemistry.chemical_classification Chitosan 030102 biochemistry & molecular biology Triglyceride Glutathione peroxidase Intestinal lipid absorption Lipogenesis Organic Chemistry Lipid metabolism General Medicine Computer Science Applications Rats 030104 developmental biology Endocrinology chemistry lcsh:Biology (General) lcsh:QD1-999 Adipose Tissue Intestinal Absorption Liver chitosan oligosaccharide Lipid Peroxidation |
Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 3 International Journal of Molecular Sciences, Vol 22, Iss 1139, p 1139 (2021) |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms22031139 |
Popis: | Chitosan and its derivative, chitosan oligosaccharide (CO), possess hypolipidemic and anti-obesity effects. However, it is still unclear if the mechanisms are different or similar between chitosan and CO. This study was designed to investigate and compare the effects of CO and high-molecular-weight chitosan (HC) on liver lipogenesis and lipid peroxidation, adipose lipolysis, and intestinal lipid absorption in high-fat (HF) diet-fed rats for 12 weeks. Rats were divided into four groups: normal control diet (NC), HF diet, HF diet+5% HC, and HF diet+5% CO. Both HC and CO supplementation could reduce liver lipid biosynthesis, but HC had a better effect than CO on improving liver lipid accumulation in HF diet-fed rats. The increased levels of triglyceride decreased lipolysis rate, and increased lipoprotein lipase activity in the perirenal adipose tissue of HF diet-fed rats could be significantly reversed by both HC and CO supplementation. HC, but not CO, supplementation promoted liver antioxidant enzymes glutathione peroxidase and superoxide dismutase activities and reduced liver lipid peroxidation. In the intestines, CO, but not HC, supplementation reduced lipid absorption by reducing the expression of fabp2 and fatp4 mRNA. These results suggest that HC and CO have different mechanisms for improving lipid metabolism in HF diet-fed rats. |
Databáze: | OpenAIRE |
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