Effects and Mechanisms of Chitosan and ChitosanOligosaccharide on Hepatic Lipogenesis and Lipid Peroxidation, Adipose Lipolysis, and Intestinal Lipid Absorption in Rats with High-Fat Diet-Induced Obesity

Autor: Shing-Hwa Liu, Rui-Yi Chen, Meng-Tsan Chiang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Lipolysis
Adipose tissue
Diet
High-Fat

Catalysis
Article
high-fat diet-fed rats
Inorganic Chemistry
Lipid peroxidation
lcsh:Chemistry
Rats
Sprague-Dawley

03 medical and health sciences
chemistry.chemical_compound
high-molecular-weight chitosan
Internal medicine
lipid metabolism
medicine
Animals
Obesity
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Chitosan
030102 biochemistry & molecular biology
Triglyceride
Glutathione peroxidase
Intestinal lipid absorption
Lipogenesis
Organic Chemistry
Lipid metabolism
General Medicine
Computer Science Applications
Rats
030104 developmental biology
Endocrinology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Adipose Tissue
Intestinal Absorption
Liver
chitosan oligosaccharide
Lipid Peroxidation
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1139, p 1139 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms22031139
Popis: Chitosan and its derivative, chitosan oligosaccharide (CO), possess hypolipidemic and anti-obesity effects. However, it is still unclear if the mechanisms are different or similar between chitosan and CO. This study was designed to investigate and compare the effects of CO and high-molecular-weight chitosan (HC) on liver lipogenesis and lipid peroxidation, adipose lipolysis, and intestinal lipid absorption in high-fat (HF) diet-fed rats for 12 weeks. Rats were divided into four groups: normal control diet (NC), HF diet, HF diet+5% HC, and HF diet+5% CO. Both HC and CO supplementation could reduce liver lipid biosynthesis, but HC had a better effect than CO on improving liver lipid accumulation in HF diet-fed rats. The increased levels of triglyceride decreased lipolysis rate, and increased lipoprotein lipase activity in the perirenal adipose tissue of HF diet-fed rats could be significantly reversed by both HC and CO supplementation. HC, but not CO, supplementation promoted liver antioxidant enzymes glutathione peroxidase and superoxide dismutase activities and reduced liver lipid peroxidation. In the intestines, CO, but not HC, supplementation reduced lipid absorption by reducing the expression of fabp2 and fatp4 mRNA. These results suggest that HC and CO have different mechanisms for improving lipid metabolism in HF diet-fed rats.
Databáze: OpenAIRE