Spectrum of thyroid dysfunction and dementia: a dose–response meta-analysis of 344,248 individuals from cohort studies
| Autor: | Marly Augusto Cardoso, Zhi-Hui Song, Xingyao Tang, Jian-Bo Zhou, Jin-Kui Yang, Rafael Simó, Dawei Wang |
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| Přispěvatelé: | Institut Català de la Salut, [Tang X] Beijing Tongren Hospital, Capital Medical University, Beijing, China. [Song ZH] Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [Wang D] General Practice Department, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [Yang J, Zhou JB] Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [Augusto Cardoso M] Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil. [Simó R] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Unitat de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2021 |
| Předmět: |
Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia [DISEASES]
endocrine system Pediatrics medicine.medical_specialty endocrine system diseases thyroid dysfunction Endocrinology Diabetes and Metabolism Hipertiroïdisme - Complicacions Diàtesi 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] 03 medical and health sciences 0302 clinical medicine Endocrinology Internal Medicine medicine Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Thyroid Hormones [CHEMICALS AND DRUGS] Dementia Risk factor Subclinical infection enfermedades del sistema endocrino::enfermedades tiroideas::hipertiroidismo [ENFERMEDADES] enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia [ENFERMEDADES] business.industry Research Thyroid Thyroid dysfunction ESTUDOS DE COORTES RC648-665 medicine.disease Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism [DISEASES] Dose-response meta-analysis Meta-analysis medicine.anatomical_structure Demència - Factors de risc hormonas sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas tiroideas [COMPUESTOS QUÍMICOS Y DROGAS] dose–response Thyroid function business 030217 neurology & neurosurgery dementia Other subheadings::Other subheadings::/complications [Other subheadings] Hormone Cohort study |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientia Endocrine Connections Endocrine Connections, Vol 10, Iss 4, Pp 410-421 (2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/ec-21-0047 |
| Popis: | Dementia; Dose-response; Thyroid dysfunction Demència; Dosi-resposta; Disfunció de la tiroide Demencia; Dosis-respuesta; Disfunción tiroidea Thyroid hormone, as a modifiable risk factor for dementia, promotes neurocognitive function and regulates metabolic processes. Various studies have defined different thyroid-stimulating hormone cutoffs, but the safest thyroid-stimulating hormone concentration was absent. A dose–response meta-analysis describing the overall functional relation and identifying exposure intervals associated with a higher or lower disease risk is thus desirable. Therefore, our current analysis was conducted to understand the influence of thyroid dysfunction on dementia risk. We searched PubMed, Embase, and Web of Science before May 1, 2020 for human studies published in English. Studies were considered for inclusion if they used a cohort study design to measure the risk of dementia in different thyroid function status groups, diagnosed thyroid functional status and all-cause dementia, included participants aged >18 years, and provided quantitative measures of data. The analysis contained 17 articles with 344,248 individuals with a 7.8-year mean follow-up. Ten studies with 329,287 participants indicated that only subclinical hyperthyroidism was associated with an increased risk of dementia. In contrast, subclinical hypothyroidism, clinical hyperthyroidism, and clinical hypothyroidism did not affect dementia. In the dose–response meta-analysis with 46,417 samples from 11 studies, the association of thyroid-stimulating hormone with the risk of dementia exhibited a U-shaped curve. Our study indicated that subclinical hyperthyroidism was associated with the risk of dementia and the thyroid-stimulating hormone concentration at around 1.55–1.60 mU/L as the optimum range for the risk of dementia. This work was supported by the National Natural Science Foundation of China (No. 82070851, 81870556, 81930019, 81670738), Beijing Municipal Administration of Hospital’s Youth Program (QML20170204), Excellent Talents in Dongcheng District of Beijing. |
| Databáze: | OpenAIRE |
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