Improvement of peripheral nerve defects using a silicone conduit filled with hepatocyte growth factor
| Autor: | Azadeh Khaleghjoo, Keyvan Amini, Masoume Masoumi-Verki, Rahim Mohammadi, Sima Ahsan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Silicones Pathology and Forensic Medicine Immunoenzyme Techniques Random Allocation chemistry.chemical_compound Gastrocnemius muscle Silicone Peripheral nerve Animals Humans Medicine Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Rats Wistar Saline Hepatocyte Growth Factor business.industry Regeneration (biology) Recovery of Function Sciatic Nerve Facial nerve Nerve Regeneration Rats nervous system chemistry Anesthesia Surgery Hepatocyte growth factor Sciatic nerve Oral Surgery business medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 116:673-679 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2013.07.006 |
| Popis: | To assess local effects of hepatocyte growth factor (HGF) on peripheral nerve repair in a rat sciatic nerve transection model.Sixty male, healthy, white Wistar rats were randomized into 4 experimental groups: In the sham-operated group, sciatic nerve was exposed and manipulated. In the transected control group, the left sciatic nerve was transected. In the silicone graft group (SIL), a 10-mm defect was made and bridged using a silicone tube. The graft was filled with phosphate-buffered saline in the SIL group and with HGF in the SIL/HGF group.Behavioral testing, sciatic nerve functional study, gastrocnemius muscle mass measurement, and morphometric indices found earlier regeneration of axons in the SIL/HGF than in the SIL group (P.05). Immunohistochemical study clearly found more positive location of reactions to S-100 in the SIL/HGF group than in the SIL group.HGF may have clinical implications for the surgical management of patients after facial nerve transection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect