Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study
| Autor: | Xiao-Dong Mo, Ming-Feng Zhao, Yu Wang, Huan Chen, Lan-Ping Xu, Le-Qing Cao, Chen-Hua Yan, Shu-Zhen Zhai, Feng-Rong Wang, Xiao-Jun Huang, Kai-Yan Liu, Yu-Qian Sun, Yajing Xu, Wei Han, Ying-Jun Chang, Yu-Hong Chen, Xiao-Hui Zhang, Meng Lv, Ming-Rui Huo, Fei-Fei Tang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male China Multivariate analysis Adolescent Waiting Lists Immunology Anti-HLA antibody Human leukocyte antigen 030230 surgery 03 medical and health sciences Young Adult 0302 clinical medicine HLA Antigens Isoantibodies Risk Factors Prevalence Immunology and Allergy Medicine Humans Child Aged biology business.industry Infant General Medicine Middle Aged Transplant Recipients Transplantation Multi center study Child Preschool Transplantation Haploidentical biology.protein Female Stem cell Antibody business 030215 immunology Stem Cell Transplantation |
| Zdroj: | Human immunology. 79(9) |
| ISSN: | 1879-1166 |
| Popis: | We investigated the prevalence of and risk factors for antibodies to HLA in 1663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P = 0.018), prior transfusions (P 0.001) or pregnancy (P 0.001), and cases with MDS (P = 0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P = 0.017); and ii) risk factors associated with the prevalence of PRA both for class I and class II HLA were female gender (P = 0.014), prior transfusions (P = 0.003), previous pregnancy (P 0.001), and diagnosis with MDS (P = 0.035). The percentages of antibodies against different antigens coded by the different HLA loci, including HLA-A, -B, -C, -DP, -DQ, and -DR, among all cases were 15.6%, 17.3%, 10.5%, 5.6%, 8.5%, and 9.7%, respectively. Risk factors associated with specific antibodies against HLA-A, -B, -C, -DP, -DQ, and -DR were female gender, prior transfusion, previous pregnancy, and underlying disease. Our findings suggest that gender, prior pregnancy, transfusion and underlying diseases are risk factors for HLA sensitization, which could guide HLA antibody monitor and donor selection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect