Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice
| Autor: | Taku Kaitsuka, Kimi Araki, Rika Fujino, Jun Chen, Tetsuro Yamamoto, Kazuhito Tomizawa |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Ribosomal Proteins 0301 basic medicine Elevated plus maze Conditioning Classical Mice Transgenic Anxiety Biology Bioinformatics medicine.disease_cause complex mixtures Monocytes Mice 03 medical and health sciences 0302 clinical medicine Memory Ribosomal protein S19 medicine Animals Gene Knock-In Techniques Receptor Mutation Chemotaxis General Neuroscience Fear Ligand (biochemistry) Grooming Cell biology Complement system Mice Inbred C57BL Freezing behavior 030104 developmental biology 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Neuroscience Letters. 629:221-226 |
| ISSN: | 0304-3940 |
| Popis: | Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior. |
| Databáze: | OpenAIRE |
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