The effect of insulin pump therapy in retinal vasculature in type 1 diabetic patients
| Autor: | Ana Vide-Escada, Tomás Loureiro, Ana Rita Carreira, Sandra Rodrigues-Barros, Nuno Campos, Joao Cardoso, Carlos Diogo Pinheiro Lima Lopes |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Insulin pump
Adult Blood Glucose medicine.medical_specialty Injections Subcutaneous 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Insulin Infusion Systems Internal medicine medicine Humans Hypoglycemic Agents Insulin Prospective Studies Glycated Hemoglobin Type 1 diabetes Retina business.industry Retinal Vessels Retinal General Medicine Diabetic retinopathy Middle Aged medicine.disease Subcutaneous insulin Ophthalmology Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 1 chemistry Metabolic control analysis 030221 ophthalmology & optometry business |
| Zdroj: | European journal of ophthalmology. 31(6) |
| ISSN: | 1724-6016 |
| Popis: | Background/objectives: Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vasculature. Methods: We performed a prospective study with type 1 diabetic patients with no prior history of ocular pathology other than mild diabetic retinopathy. The patients were divided into two groups according to their therapeutic modality (CSII vs MDI). The retinal nerve fiber layers thickness and vascular densities were compared between groups in both macula and optic disc. The correlations between vascular density and clinical features were also determined. Statistical significance was defined as p Results: The study included 52 eyes, 28 in the insulin CSII group. The mean age was 36.66 ± 12.97 years, with no difference between groups ( p = 0.49). The mean glycated hemoglobin (HbA1c) was found to be lower in the CSII group (7.1% ± 0.7 vs 7.5% ± 0.7 p Conclusion: We found that CSII provided better metabolic control than MDI and this seemed to result in higher parafoveal vascular density. As lower vascular density is associated with an increased risk of diabetic retinopathy, these results suggest that CSII could be the safest therapeutic option to prevent retinopathy. |
| Databáze: | OpenAIRE |
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