Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016

Autor: Kishore Sarma, Kimmi Sarmah, Dipankar Biswas, Rahul Hazarika, Mandakini Das, Aniruddha Jakharia, Biswajyoti Borkakoty, Palash Kumar Das
Rok vydání: 2018
Předmět:
Zdroj: 3 Biotech. 8
ISSN: 2190-5738
2190-572X
DOI: 10.1007/s13205-018-1427-4
Popis: Since its emergence in 2009, Influenza A/H1N1pdm09 virus has evolved continuously. Marked genetic variations have occurred in the HA1 domain of the hemagglutinin gene causing the emergence of new variants. The present study genetically characterized the hemagglutinin (HA) gene of Influenza A/H1N1pdm09 strains from Assam circulating in 2016 that caused a mild outbreak without any reported mortality. Sequence analysis of the HA gene of 20 positive Assam/H1N1pdm09 strains revealed 3 mutations (K180Q, S202T, S220T) at the antigenic sites along with several other reported mutations which are in close proximity to the antigenic sites and therefore might affect the viral antigenicity. Phylogenetically, the Assam/H1N1pdm09 strains clustered into genogroup 6B. These genetic variations highlight the importance of continuous surveillance and characterization of Influenza A/H1N1pdm09 virus activity to track the genetic makeup and diversification that may affect the behavior of the virus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13205-018-1427-4) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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