New bioaffine sorbents for selective elimination of autoantibodies against human thyroperoxidase in autoimmune thyroid diseases
| Autor: | O. V. Gribovskaya, V. P. Martinovich, I V Shutova, O V Tsyganova, V. P. Golubovich |
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| Rok vydání: | 2012 |
| Předmět: |
Acrylic Resins
Iodide Peroxidase Chromatography Affinity General Biochemistry Genetics and Molecular Biology Autoimmune Diseases Sepharose Epitopes Antigen Thyroid peroxidase medicine Humans Polyacrylamide gel electrophoresis Autoantibodies biology Chemistry Thyroid Autoantibody General Medicine Immunosorbents Enzymes Immobilized Ligand (biochemistry) Thyroid Diseases medicine.anatomical_structure Immunology biology.protein Oligopeptides |
| Zdroj: | Biomeditsinskaya Khimiya. 58:211-219 |
| ISSN: | 2310-6905 2310-6972 |
| DOI: | 10.18097/pbmc20125802211 |
| Popis: | New bioaffine sorbents containing bioselective ligand, synthetic analog of the human thyroperoxidase antigenic determinant - tetrapeptide H-Glu-Gln-βAla-Lys-OMe, immobilized on two polymeric matrixes - a polyacrylamide gel and CNBr-activated sepharose 4B were synthesized. The offered immunosorbents were shown have high selectivity in relation to autoantibodies against thyroperoxidase and can find an application for medicine and experimental biochemistry for selective elimination of autoantibodies from serum or plasma of the patients suffering from autoimmune thyroid diseases. |
| Databáze: | OpenAIRE |
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