Treatment of cryptorchidism with a potent analog of gonadotropin-releasing hormone
| Autor: | Jürgen Beyer, Aliza Eshkol, Wolfgang Callensee, Thomas Weber, Johann August Ermert, Joachim Happ |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Gonadotropin-releasing hormone Internal medicine Cryptorchidism Medicine Precocious puberty Humans Child business.industry Obstetrics and Gynecology Infant GnRH Analog Luteinizing Hormone medicine.disease Gonadotropin secretion Endocrinology Reproductive Medicine Child Preschool Antibody Formation Once daily Follicle Stimulating Hormone business Pituitary Hormone-Releasing Hormones hormones hormone substitutes and hormone antagonists After treatment Gonadotropins Hormone |
| Zdroj: | Fertility and sterility. 29(5) |
| ISSN: | 0015-0282 |
| Popis: | Pernasal therapy of cryptorchidism with D-Leu6-des-Gly10-gonadotropin-releasing hormone ethylamide (D-Leu6-des-Gly10-GnRH-EA), a potent, long-acting GnRH analog, was attempted. Eleven prepubertal cryptorchid boys received between 25 microgram once daily and 25 to 50 microgram twice daily for 5 to 12 weeks. Complete testicular descent was achieved in 4 of the 11 boys. GnRH tests (1.5 microgram/kg intravenously), conducted in six boys before treatment, after 4 weeks of treatment, and in 2 boys 3 months after treatment, did not reveal changes in gonadotropin secretion indicative of precocious puberty or of decreased hypophyseal sensitivity to GnRH. Antibodies to the GnRH analog or to GnRH could not be detected. |
| Databáze: | OpenAIRE |
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