A Glucose-Responsive Polymer Nanocarrier Based on Sulfonated Resorcinarene for Controlled Insulin Delivery
Autor: | Anastasia S. Sapunova, Tatiana Yu. Sergeeva, Irek R. Nizameev, Alexandra D. Voloshina, Timur A. Mukhametzyanov, Igor S. Antipin, Marsil K. Kadirov, Rezeda K. Mukhitova, Albina Y. Ziganshina |
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Rok vydání: | 2019 |
Předmět: |
Polymers
medicine.medical_treatment Phenylalanine 010402 general chemistry 01 natural sciences Dissociation (chemistry) Fluorescence spectroscopy Drug Delivery Systems Blood plasma medicine Humans Insulin Type 1 diabetes Drug Carriers Chromatography 010405 organic chemistry Chemistry General Chemistry Resorcinarene medicine.disease Boronic Acids 0104 chemical sciences Drug Liberation Diabetes Mellitus Type 1 Glucose Drug delivery Nanocarriers Calixarenes Sulfonic Acids |
Zdroj: | ChemPlusChem. 84(10) |
ISSN: | 2192-6506 |
Popis: | A nanocarrier (p(6SRA-5B)) for glucose-controlled insulin delivery consists of sulfonated resorcinarenes (SRA) that are assembled into a spherical shell and are attached to each other with phenylboronate linkers. p(6SRA-5B) is stable in water and blood plasma at normal glucose concentrations. At high glucose levels (>5 mM), p(6SRA-5B) dissociates into SRA and phenylboronates through competitive interaction with excess glucose. Insulin was successfully encapsulated into the cavity of p(6SRA-5B) and its release was investigated in water and blood plasma by NMR, UV, CD, and fluorescence spectroscopy. The results show that the dissociation of the nanocarrier and the insulin release occurs with an increase in glucose concentration. At 5 mM glucose, the nanocarrier is stable, and the insulin release does not exceed 10 %. Increasing the glucose concentration to 7.5-10 mM results in a 40-100 % insulin release. p(6SRA-5B) is thus a promising insulin nanocarrier for the treatment of type 1 diabetes. |
Databáze: | OpenAIRE |
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