Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Autor:	Giulia Collatuzzo, Gianfranco Alicandro, Paola Bertuccio, Claudio Pelucchi, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Weimin Ye, Amelie Plymoth, David Zaridze, Dmitry Maximovich, Nuria Aragones, Gemma Castaño-Vinyals, Jesus Vioque, Manoli Garcia de la Hera, Zuo-Feng Zhang, Jinfu Hu, Lizbeth Lopez-Carrillo, Malaquías López-Cervantes, Michela Dalmartello, Lina Mu, Mary H Ward, Charles Rabkin, Guo-Pei Yu, M Constanza Camargo, Maria Paula Curado, Nuno Lunet, Eva Negri, Carlo La Vecchia, Paolo Boffetta
Rok vydání:	2022
Předmět:	Epidemiology Settore MED/06 - Oncologia Medica Settore MED/42 - Igiene Generale e Applicata Alcohol Gastric cancer Mediation analysis Peptic ulcer disease Salt Smoking Socioeconomic status Public Health Environmental and Occupational Health Settore MED/01 - Statistica Medica
Zdroj:	JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname
ISSN:	0143-005X
Popis:	BackgroundPeptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC.MethodsWe conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC.ResultsPUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC.ConclusionsOur study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.
Databáze:	OpenAIRE
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