Slit and robo: expression patterns in lung development
| Autor: | Mark Anselmo, Jane Y. Wu, Katsumi Komatsuzaki, Sussie Dalvin, Parthak Prodhan, Jeremy T. Aidlen, T. Bernard Kinane, Jay J. Schnitzer |
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| Rok vydání: | 2003 |
| Předmět: |
genetic structures
Mesenchyme Nerve Tissue Proteins Biology Mice Genetics medicine Animals Drosophila Proteins Receptors Immunologic Lung Molecular Biology Gene Expression Profiling Cell migration respiratory system Embryonic stem cell Slit eye diseases respiratory tract diseases Cell biology medicine.anatomical_structure Immunology Roundabout Immunohistochemistry Respiratory epithelium sense organs Developmental Biology |
| Zdroj: | Gene Expression Patterns. 3:13-19 |
| ISSN: | 1567-133X |
| DOI: | 10.1016/s1567-133x(02)00095-9 |
| Popis: | First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-1 and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-1 and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development. |
| Databáze: | OpenAIRE |
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