The evaluation of thiol-disulfite balance, ischemia albumin modification and seruloplazmine as a new oxidative stress in mild cognitive impairment and early stage alzheimer's disease patients
| Autor: | Yahya Karaman, Enishan Zorlu, Neslihan Bukan, Neslihan Gürbüz, Ozcan Erel, Salim Neselioglu, Yasemin Gündüztepe, Tuğberk Andaç Topkan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology medicine.medical_specialty Population Ischemia Serum Albumin Human Disease Calorimetry medicine.disease_cause 03 medical and health sciences Cognition 0302 clinical medicine Alzheimer Disease Physiology (medical) Internal medicine medicine Humans Sulfites Dementia Cognitive Dysfunction Sulfhydryl Compounds education Aged Aged 80 and over education.field_of_study business.industry General Medicine Middle Aged medicine.disease Oxidative Stress Early Diagnosis Neurology 030220 oncology & carcinogenesis Biomarker (medicine) Female Surgery Neurology (clinical) Alzheimer's disease business Biomarkers 030217 neurology & neurosurgery Oxidative stress Follow-Up Studies |
| Popis: | Background Alzheimer's Disease (AD) is the most common form of dementia seen in advanced age. It is characterized by progressive deterioration in cognitive functions. The prevalence of Alzheimer's disease increasing day by day due to the increase in the share of the elderly population in the general population due to developing health and living conditions, is limited and early diagnosis and effective treatment possibilities are very limited. From this point of view, a specific biomarker for AD is very important. As a new oxidative stress biomarker, the levels of thiol-disulfide balance, ischemia-modified albumin and seroloplazminin were evaluated. The aim of this study was to determine the serum levels of oxidative stress biomarkers in the early stages of the disease and to compare these oxidative stress markers with patients with mild cognitive impairment as a precursor form of Alzheimer's disease and to determine whether these markers develop at an earlier stage. Methods 30 volunteers with early stage AD according to NINCDS-ARDRA criteria, 19 volunteers with Midl Cognitive Impairment according to PCA criteria and 30 volunteers with defined criteria were selected from the subjects aged between 55 and 88 who applied to Gazi University Health Research. Statistical analysis of the data showed that there was a significant difference between the endgroups and biomarkers for the early diagnosis of Alzheimer's disease, but this complicated matter has to be investigated in more comprehensive and detailed studie. Results In the present study, we investigated oxidative stress parameters, thiol-disulphide balance, ischemia modified abumin and seruloplasmin in parallel with the impairment in cognitive dysfunction from control group to Mild Cognitive Impairment (MCD) and AD group by using a newly-developed method. Conclusions This is the first study in literature comparing Early Stages Alzheimer Disease (ESAD), MCD and healthy volunteer groups. Our study has revealed that these newly developed tests may be candidates as oxidative stress biomarkers in pathgenesis of AD. However it was concluded that more comprehensive and detailed studies are required to enlighten this issue. |
| Databáze: | OpenAIRE |
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