Steady-State Evaluation of Twice-a-Day Dosing of a New Sustained-Release Theophylline Preparation for Young Children
| Autor: | Orgel Ha, Welch Mj, James P. Kemp, Eli O. Meltzer |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Time Factors medicine.drug_class Absorption (skin) Absorption Theophylline Bronchodilator medicine Humans Immunology and Allergy Dosing Child Asthma Morning business.industry medicine.disease Bioavailability Child Preschool Delayed-Action Preparations Anesthesia Pediatrics Perinatology and Child Health Female Steady state (chemistry) business medicine.drug |
| Zdroj: | Journal of Asthma. 22:249-252 |
| ISSN: | 1532-4303 0277-0903 |
| Popis: | We studied the absorption properties of a new sustained-release theophylline, Theo-Dur Sprinkle (TS), to see if this formulation when given on a b.i.d. basis results in acceptable steady-state theophylline levels in children with asthma. Twelve patients (ages 5-8 years), after multiple TS dosing, had serum theophylline levels determined over a 10-hr period after a morning TS dose. Fluctuations in serum theophylline concentrations were acceptable with the observed mean percent peak-to-trough fluctuation [(peak-trough/trough) x 100] being 53%. Patients required higher than usually recommended theophylline doses to obtain therapeutic levels, suggesting incomplete absorption of TS; this was documented with one patient using a 100% bioavailable theophylline product as a comparison. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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