Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS)
| Autor: | Yasuo Akanuma, Hirohito Sone, Chika Horikawa, Shiro Tanaka, Yukio Yoshimura, Chiemi Kamada, Sachiko Tanaka, Tatsumi Moriya, Kazuya Fujihara, Atsushi Araki, Rei Aida |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Nutritional Status Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes Cohort Studies 03 medical and health sciences 0302 clinical medicine Japan Internal medicine Diabetes mellitus medicine Humans Prospective Studies Aged Diabetic Retinopathy 030109 nutrition & dietetics Nutrition and Dietetics business.industry Incidence Diabetic retinopathy Middle Aged medicine.disease Vitamin B 6 Diet Diabetes Mellitus Type 2 Quartile Dietary Reference Intake Vitamin B Complex Cohort Female business Body mass index Retinopathy |
| Zdroj: | European Journal of Nutrition. 59:1585-1594 |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-019-02014-4 |
| Popis: | Although vitamin B6 has been suspected to prevent the progression of diabetic retinopathy, evidence of this in patients with type 2 diabetes based on longitudinal studies is sparse. This study investigated the relationship between vitamin B6 intake and the incidence of diabetic retinopathy in Japanese patients with type 2 diabetes. The study was part of an examination of a nationwide cohort of patients with type 2 diabetes aged 40–70 years with HbA1c ≥ 48 mmol/mol. After excluding nonresponders to a dietary survey using the Food Frequency Questionnaire based on food groups, 978 patients were analyzed. Primary outcome was the 8-year risk of a diabetic retinopathy event, and Cox regression analyses estimated hazard ratios (HRs) for retinopathy according to vitamin B6 intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. Mean vitamin B6 intake in quartiles ranged from 1.1 to 1.6 mg/day, and half of the participants had vitamin B6 intake below the recommended daily dietary allowance according to dietary reference intakes in Japanese adults (men 1.4 mg/day; women 1.2 mg/day). After adjusting for confounders, HRs for diabetic retinopathy in the 2nd, 3rd, and 4th quartile groups of vitamin B6 intake compared with the 1st quartile group were 1.17 (95% confidence interval 0.81–1.69, p = 0.403), 0.88 (0.58–1.34, p = 0.550), and 0.50 (0.30–0.85, p = 0.010), respectively. Findings suggested that high vitamin B6 intake was associated with a lower incidence of diabetic retinopathy in Japanese with type 2 diabetes. |
| Databáze: | OpenAIRE |
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