Toll-like signaling pathway in the transcriptome of Littorina littorea
| Autor: | Alexander M. Gorbushin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
TIRAP Gastropoda Trematode Infections Aquatic Science Biology Transcriptome 03 medical and health sciences Immune system Downregulation and upregulation Environmental Chemistry Animals Receptor Gene Toll-Like Receptors 04 agricultural and veterinary sciences General Medicine Cell biology 030104 developmental biology TRIF 040102 fisheries 0401 agriculture forestry and fisheries Trematoda Signal transduction Signal Transduction |
| Zdroj: | Fishshellfish immunology. 106 |
| ISSN: | 1095-9947 |
| Popis: | The transcriptome of the caenogastropod mollusk Littorina littorea was scanned for the presence of sequences encoding Toll-like receptors (TLRs) and corresponding proteins involved in downstream TLR signaling pathway. In the transcriptomic snapshots of hemocytes and kidney tissues, 45 complete TLRs encoded by 35 genes were identified. Out of the 59 non-TLR molecules involved in a canonical TLR signaling pathway, 35 genes were classified as homologous and could be placed within the TLR-mediated MyD88-and MAPK-dependent circuitries. No reference vertebrate adapters TIRAP, TRIF and TRAM were identified in the transcriptome. The results of RNA-seq experiments with an immune challenge (rediae of the digenean Himasthla elongata) indicate that four TLRs (LlTLR1, 3, 5 and 8) and a set of upregulated genes involved in signal transduction (LlMyd88, LlTNFα, LlCASP8, LlFADD, LlNFKBIA (IkBα), LlIRAK1, LlSTAT1, LlMAPK14 (P38), LlMAP2K1 (MEK1/2), LlIRF3 and LlIRF5) may participate in the anti-digenean immune response of L. littorea. |
| Databáze: | OpenAIRE |
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