Asymmetric IrI-Catalysed Allylic Alkylation Of Monosubstituted Allylic Acetates With Phosphorus Amidites As Ligands

Autor:	Cristina García-Yebra, Guenter Helmchen, Bjoern Bartels
Rok vydání:	2003
Předmět:	Allylic rearrangement Denticity Chemistry Phosphorus Organic Chemistry Enantioselective synthesis chemistry.chemical_element General Medicine Medicinal chemistry Catalysis Tsuji–Trost reaction Organic chemistry Iridium Physical and Theoretical Chemistry Chirality (chemistry)
Zdroj:	ResearcherID
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200390162
Popis:	Monodentate phosphorus amidites derived from 2,2′-binaphthol and a variety of chiral amines were employed as ligands in IrI-catalysed allylic alkylations of unsymmetrically substituted allylic acetates. The enantio- and regioselectivities of these reactions were investigated. Phosphorus amidites of bulky secondary chiral amines induced enantioselectivities of up to 94% ee in reactions of linear substrates. Phosphorus amidites derived from chiral primary amines, which have not been previously employed in asymmetric catalysis, furnished improved regioselectivities. The use of LiCl as additive led to improved regio- and enantioselectivities. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Databáze:	OpenAIRE
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