A Case-by-Case Protocol of Membranous Nephropathy Treatment with Endovenous Infusion of High Doses of Human Immunoglobulins
| Autor: | Lorena Nostro, Giuseppe Coppolino, Donatella Tripodo, Maria Stella Giacobbe, Buemi M, Susanna Campo, Davide Bolignano, Fulvio Floccari, Vincenzo Cosentini |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Nephrology Human immunoglobulins medicine.medical_specialty intravenous human immunoglobulins Spontaneous remission Glomerulonephritis Membranous Gastroenterology Drug Administration Schedule Statistics Nonparametric Membranous nephropathy Internal medicine medicine Humans Immunologic Factors Vein Serum Albumin Aged Retrospective Studies Proteinuria business.industry Remission Induction Immunoglobulins Intravenous membranous nephropathy Blood Proteins General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Female medicine.symptom business Perfusion Kidney disease |
| Zdroj: | Nephron Clinical Practice. 108:c113-c120 |
| ISSN: | 1660-2110 |
| Popis: | The treatment of membranous nephropathy is a highly controversial issue. As some patients may have spontaneous remission, in about 50% of cases the risk of treating patients with drugs that may have severe side effects is higher than the potential benefit of arresting disease progression. Some authors therefore propose exclusively symptomatic treatment; other authors use steroids and immunosuppressive drugs, alone or in association with high risk of adverse effects and often uncertain benefits. The intravenous administration of high doses of human immunoglobulins (IVIg) has been also extended to a growing number of kidney diseases including membranous nephropathy. The mechanisms through which IVIg carry out their therapeutic effect are still unclear. The present study is a retrospective and uncontrolled trial, the aim of which was firstly to verify if some patients could respond to extremely short treatment protocols, stopped when they appear to have a stable remission, thereby avoiding expensive continuation of treatment. Secondly, we aimed to verify if some patients, judged as nonresponders to a classical protocol of IVIg therapy, could respond to a more prolonged treatment. |
| Databáze: | OpenAIRE |
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