Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults: Results of a 1-year european multi-center trial
| Autor: | Claudio Franceschi, Agnes A M Berendsen, Rachel Gillings, Anne Marie Minihane, Ewa Sicinska, Amy Jennings, Anna Brzozowska, Edith J. M. Feskens, Nathalie Meunier, Susan J. Fairweather-Tait, Barbara Pietruszka, Elodie Caumon, Aedin Cassidy, Corinne Malpuech-Brugère, Colette M. O’ Neill, Rita Ostan, Aurelia Santoro, Lisette C. P. G. M. de Groot |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry potassium pulse wave velocity aging blood pressure 030204 cardiovascular system & hematology medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine Blood pressure Internal medicine Arterial stiffness medicine Cardiology Internal Medicine 030212 general & internal medicine business Pulse wave velocity sodium |
| Zdroj: | Jennings, A, Berendsen, A M, De Groot, L C P G M, Feskens, E J M, Brzozowska, A, Sicinska, E, Pietruszka, B, Meunier, N, Caumon, E, Malpuech-Brugère, C, Santoro, A, Ostan, R, Franceschi, C, Gillings, R, O'Neill, C M, Fairweather-Tait, S J, Minihane, A M & Cassidy, A 2019, ' Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults: Results of a 1-year european multi-center trial ', Hypertension, vol. 73, no. 3, pp. 578-586 . https://doi.org/10.1161/HYPERTENSIONAHA.118.12259 |
| DOI: | 10.1161/HYPERTENSIONAHA.118.12259 |
| Popis: | We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P =0.03), which was evident in males (−9.2 mm Hg, P =0.02) but not females (−3.1 mm Hg, P =0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P =0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P =0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P =0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P =0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness. Clinical Trial Registration— URL: http://www.clinicialtrials.gov . Unique identifier: NCT01754012. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|