Impact of patient and disease characteristics on therapeutic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German noninterventional observational study
| Autor: | Ekkehard Röther, B. Wittig, Wolfgang Spieler, Stefan Kleinert, Siegfried Wassenberg, Constanze Richter, Holger Gnann, Andreas Krause, Martin Feuchtenberger, Hans-Peter Tony |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male musculoskeletal diseases Arthritis rheumatoid medicine.medical_specialty Immunology Arthritis Antibodies Monoclonal Humanized Severity of Illness Index Sex Factors Rheumatology Germany Internal medicine Severity of illness Adalimumab Humans Immunology and Allergy Medicine Prospective Studies Prospective cohort study skin and connective tissue diseases Aged Retrospective Studies ddc:616 Tumor Necrosis Factor-alpha business.industry Age Factors Retrospective cohort study Middle Aged medicine.disease Antirheumatic agents Treatment Outcome Rheumatoid arthritis Physical therapy Regression Analysis Female Original Article Observational study business medicine.drug |
| Zdroj: | Rheumatology International |
| Popis: | The objective of this study was to use data from a noninterventional study to evaluate the effectiveness of adalimumab in rheumatoid arthritis (RA) patients during routine clinical practice and to explore the potential impact of patient and disease characteristics in response to adalimumab therapy. A total of 2,625 RA patients with specified data at baseline (prior to initiating adalimumab treatment) and 12 months entered this study between April 2003 and March 2009. We evaluated response to adalimumab therapy and conducted stepwise regression and subgroup analyses of factors influencing therapeutic response. During the 1-year adalimumab treatment period, disease activity decreased from a baseline mean disease activity score-28 joints (DAS28) of 5.9–3.9, while functional capacity improved from 59.0 to 68.4 Funktionsfragebogen Hannover (FFbH) percentage points. In multivariate regression models, high baseline DAS28 was the strongest positive predictor for decrease in disease activity, and high baseline functional capacity was associated with reduced gains in functional capacity. Male gender was a positive predictor of therapeutic response for both disease activity and functional capacity, while older age and multiple previous biologics were associated with a reduced therapeutic response. Subset analyses provided further support for the impact of baseline DAS28, FFbH, and prior biologic therapy on therapeutic response during treatment. We conclude that treatment with adalimumab leads to decreased disease activity and improved function during routine clinical practice. Patients with high disease activity and low functional capacity are particularly benefitted by adalimumab therapy. |
| Databáze: | OpenAIRE |
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