The substrate specificity of desaturases: The conversion of cis-12-octadecenoic acid into linoleic acid in different animal and plant species
| Autor: | A.T. James, D. Howling, M. P. Robinson, L.J. Morris, M.I. Gurr |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Octadecenoic Acid
Swine Linoleic acid Chlorella vulgaris Biophysics Hamster Chlorella Biology Tritium Biochemistry Mixed Function Oxygenases Mice chemistry.chemical_compound Mammary Glands Animal Endocrinology Species Specificity Pregnancy Cricetinae Animals Lactation Coenzyme A Candida chemistry.chemical_classification Carbon Isotopes Goats Substrate (chemistry) Yeast Rats Enzyme Linoleic Acids Liver chemistry Yield (chemistry) Fatty Acids Unsaturated Female Chromatography Thin Layer Rabbits Chickens Stearic Acids Subcellular Fractions |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 280:415-421 |
| ISSN: | 0005-2760 |
| DOI: | 10.1016/0005-2760(72)90247-0 |
| Popis: | 1. 1. The ability of cis -12-octadecenoic acid to act as a substrate for the stearoyl-CoA desaturase of hen, goat, pig, mouse, rabbit, hamster, rat, the yeast Candida utilis and the alga, Chlorella vulgaris has been tested. 2. 2. Hen, goat, pig and Chlorella vulgaris convert cis -12-octadecenoate into linoleate in good yield, rabbit and mouse in very poor yield whereas the rat, hamster and yeast enzymes do not desaturate this substrate. 3. 3. We propose that cis -12-octadecenoate is desaturated not by the stearoyl-CoA desaturase but by a second desaturase more active on saturated fatty acids with a chain length of about C 14 . This enzyme occurs in hen, goat and Chlorella vulgaris but not in rat or in Candida utilis . |
| Databáze: | OpenAIRE |
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