| Autor: |
Jose Antonio Hernandez-Pacheco, Johnatan Torres-Torres, Raigam Jafet Martinez-Portilla, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Paloma Mateu-Rogell, Miguel Angel Nares-Torices, Mario Enmanuel Lopez-Marenco, Keren Rachel Escobedo-Segura, Alejandro Posadas-Nava, Jose Rafael Villafan-Bernal, Lourdes Rojas-Zepeda, Norma Patricia Becerra-Navarro, Manuel Casillas-Barrera, Mauricio Pichardo-Cuevas, Cinthya Muñoz-Manrique, Ivan Alonso Cortes-Ramirez, Salvador Espino-y-Sosa |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Medicine. 9 |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2022.894633 |
| Popis: |
BackgroundPreeclampsia (PE) and COVID-19 share a common vascular–endothelial physiopathological pathway that may aggravate or worsen women's outcomes when both coexist. This study aims to evaluate the association of sFlt-1 levels and adverse maternal outcomes among positive SARS-CoV-2 pregnant women with and without hypertensive disorders of pregnancy (HDP).MethodsWe performed a multicenter retrospective cohort study of pregnant women with confirmed SARS-CoV-2 infection that required hospital admission. The exposed cohort comprised women with a diagnosis of an HDP. The primary outcome was a composite definition of adverse maternal outcome. The association between predictors and the main and secondary outcomes was assessed using an elastic-net regression which comprised a Lasso and Ridge regression method for automatic variable selection and penalization of non-statistically significant coefficients using a 10-fold cross-validation where the best model if automatically chosen by the lowest Akaike information criterion (AIC) and Bayesian information criteria (BIC).ResultsAmong 148 pregnant women with COVID-19, the best predictive model comprised sFlt-1 MoMs [odds ratio (OR): 5.13; 95% CI: 2.19–12.05], and HDP (OR: 32.76; 95% CI: 5.24–205). sFlt-1 MoMs were independently associated with an increased probability of an adverse maternal outcome despite adjusting for HDP.ConclusionsOur study shows that sFlt-1 is an independent predictor of adverse outcomes in women with SARS-CoV-2 despite hypertension status. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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