Nutritional status of patients submitted to transplantation of allogeneic hematopoietic stem cells: a retrospective study
| Autor: | Luis Fernando Bouzas, Kátia Baluz, Daiane Cristina Guerra, Wander R Furtado, Érika Elias Ferreira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Nausea medicine.medical_treatment Hematopoietic stem cell transplantation Gastroenterology Hematopoietic stem cell Nutritional therapy Nutritional status Internal medicine medicine Mucositis lcsh:RC633-647.5 business.industry Retrospective cohort study lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Surgery Transplantation medicine.anatomical_structure Original Article medicine.symptom Stem cell business Body mass index transplantation |
| Zdroj: | Revista Brasileira de Hematologia e Hemoterapia v.36 n.6 2014 Revista brasileira de hematologia e hemoterapia Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC Revista Brasileira de Hematologia e Hemoterapia, Volume: 36, Issue: 6, Pages: 414-419, Published: DEC 2014 Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 6, Pp 414-419 (2014) Revista Brasileira de Hematologia e Hemoterapia |
| Popis: | a b s t r a c t Objective: This study aimed to describe and compare the nutritional status of adult patients submitted to allogeneic hematopoietic stem cell transplantation at two different time points (admission and discharge). Methods: A retrospective, descriptive and quantitative study was performed based on clinical, laboratory and nutritional data obtained from medical records of adult patients of both genders submitted to allogeneic hematopoietic stem cell transplantation in a bone marrow transplantation reference center in Rio de Janeiro in the period from 2010 to 2013. Statistical analysis was performed using the SPSS software (version 22.0). Results: Sixty-four patients were evaluated. The mean age was 42.1 ± 3.2 years and the most prevalent disease was acute myeloid leukemia (39%). There was a high prevalence of gastrointestinal symptoms including nausea (100%), vomiting (97%) and mucositis (93%). Between admission and discharge there was a significant decrease in the median weight (−2.5 kg; 71.5 vs. 68.75 kg; p-value < 0.001), body mass index (−0.9 kg/m 2 ; 24.8 vs. 24.4 kg/m 2 ; p-value < 0.001), and serum albumin levels (−0.2 g/dL; 3.7 vs. 3.6 g/dL; p-value = 0.024). The survival time after hematopoietic stem cell transplantation correlated negatively with Creactive protein at discharge (CC = −0.72; p-value < 0.001) and positively with serum albumin levels (CC = 0.56; p-value = 0.004) and with high total protein level at discharge (CC = 0.53; p-value = 0.006). Conclusion: Our results suggest that patients submitted to allogeneic hematopoietic stem cell transplantation have compromised nutritional status during the hospital stay for transplantation. |
| Databáze: | OpenAIRE |
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