Hepatectomy for liver metastases in non-colorectal, non-neuroendocrine cancer patients. The survival benefit in primary unresectable cases
Autor: | Tomonari Katayama, Tomonori Hamada, Noriaki Futakawa, Yoshiaki Maeda, Toshiki Shinohara |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Genital Neoplasms Female medicine.medical_treatment Breast Neoplasms Disease-Free Survival Young Adult Breast cancer Risk Factors Uterine cancer Internal medicine medicine Hepatectomy Humans Child Survival rate Aged Gastrointestinal Neoplasms Retrospective Studies Aged 80 and over Chemotherapy business.industry Mortality rate Liver Neoplasms Cancer General Medicine Middle Aged Prognosis medicine.disease Survival Rate Female Surgery business Ovarian cancer |
Zdroj: | International Journal of Surgery. 22:136-142 |
ISSN: | 1743-9191 |
Popis: | Background Although liver resection is widely accepted as a potentially curative treatment for colorectal liver metastases, there is an ongoing debate on the indications for hepatectomy for the treatment of liver metastases from non-colorectal primary tumors. The number of candidates for hepatectomy for non-colorectal liver metastases may increase due to advances in chemotherapy; however, the factors related to prognosis after hepatectomy for non-colorectal liver metastases have yet to be clearly elucidated. Methods The clinical outcomes of 59 patients who underwent hepatectomy for non-colorectal liver metastases at a single institute were retrospectively analyzed. Results The 5-year overall survival rate after hepatectomy for non-colorectal, non-neuroendocrine liver metastases was 30%, and 8 patients (gastric cancer (n = 2), ovarian cancer (n = 2), uterine cancer (n = 2) and breast cancer (n = 2)) survived for 5 years. The 5-year disease-free survival rate after hepatectomy was 28%. The postoperative morbidity rate was 25%; however, there were no cases of in-hospital mortality and no patients suffered liver failure. The presence of bilateral liver metastases was identified to be an independent predicting factor for poor prognosis by a multivariate analysis (P = 0.049). The survival rate of the conversion cases (initially unresectable and converted to resection after chemotherapy) was not inferior to that of primary resectable cases in terms of either overall survival or disease-free survival. Conclusion The present study demonstrates that hepatectomy for liver metastases from non-colorectal tumors is safe and that it may be a promising strategy for prolonging survival and achieving a cure. |
Databáze: | OpenAIRE |
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