IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients
| Autor: | Amr Eldardear, Aisha Alnuzha, Yousef Almohammadi, Atiyeh M Abdallah, Khalid M. Al-Harbi, Abdulhadi H. Al-Mazroea, Ala Y. AlSamman |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Heart disease Genotype Saudi Arabia Disease Polymorphism Single Nucleotide 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Humans Genetic Predisposition to Disease Young adult Allele Promoter Regions Genetic Genetic Association Studies Genetics business.industry Haplotype Case-control study Rheumatic Heart Disease medicine.disease Genotype frequency Interleukin-10 030104 developmental biology Haplotypes Case-Control Studies Pediatrics Perinatology and Child Health Immunology Female Cardiology and Cardiovascular Medicine business 030215 immunology |
| Zdroj: | Pediatric cardiology. 37(1) |
| ISSN: | 1432-1971 |
| Popis: | Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms and RHD in Saudi Arabian patients. IL10 promoter polymorphisms (-1082A/G, -829C/T, and -592C/A) were genotyped in 118 RHD patients and 200 matched controls using the TaqMan allelic discrimination assay. There was a significant difference in IL10-1082 genotype frequency between patients and controls (p = 0.01). -1082G allele carriage (GG+GA vs AA) and the (-1082, -819, -592) GCC haplotype carriage were associated with an increased risk of RHD (p = 0.004, OR 2.1, 95% CIs 1.7-3.4 and p = 0.004, OR 2, 95% CIs 1.3-3.4, respectively). The ACC haplotype was associated with a decrease in RHD risk (p = 0.015, OR 0.6, 95% CIs 0.4-0.9). IL10 promoter polymorphisms may play an important role in the development of RHD and provide an opportunity for therapeutic stratification. |
| Databáze: | OpenAIRE |
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