Inhibitory effect of medroxyprogesterone acetate on angiogenesis induced by human endometrial cancer
| Autor: | Naoki Terakawa, Reiko Yamamoto, Yoshinobu Nishikawa, Hiroaki Jikihara, Nobuyuki Terada, Osamu Tanizawa, Keishi Matsumoto |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Angiogenesis Medroxyprogesterone Acetate Adenocarcinoma Endometrium Cornea Neovascularization Internal medicine Animals Humans Medicine Medroxyprogesterone acetate Neovascularization Pathologic business.industry Endometrial cancer Obstetrics and Gynecology Cancer Transforming Growth Factor alpha medicine.disease eye diseases Endometrial Neoplasms Transplantation Endocrinology medicine.anatomical_structure Cancer research Fibroblast Growth Factor 1 Female Rabbits sense organs medicine.symptom business Neoplasm Transplantation medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 167:207-211 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(11)91659-7 |
| Popis: | Objective: The purpose of this study was to investigate the effect of medroxyprogesterone acetate on angiogenesis induced by endometrial cancer and to elucidate the possible mechanisms by which it inhibits the growth of the cancer. Study Design: Tumors were obtained from 29 patients with endometrial adenocarcinoma, and angiogenesis was assayed in corneas of white rabbits. Results: Transplantation of tumor tissues into rabbit corneas induced angiogenesis in 70.4% of the corneas, but their transplantation with a pellet of medroxyprogesterone acetate induced angiogenesis in only 21.5% of the corneas. This compound also inhibited angiogenesis induced by acidic fibroblast growth factor and transforming growth factor-α. Conclusion: Inhibition of angiogenesis may be one mechanism by which medroxyprogesterone acetate inhibits the growth of endometrial adenocarcinoma, and its inhibition of neovascularization induced by adenocarcinoma may be through its direct action on endothelial cells. |
| Databáze: | OpenAIRE |
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