New penem compounds with 5'-substituted pyrrolidinylthio group as a C-2 side chain; comparison of their biological properties with those of carbapenem compounds
| Autor: | Haruki Matsumura, Takaaki Inoue, Masatomo Fukasawa, Makoto Sunagawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Carbapenem Lactams Stereochemistry Chemistry Microbial Sensitivity Tests Gram-Positive Bacteria Anti-Bacterial Agents Structure-Activity Relationship Carbapenems Drug Stability Group (periodic table) Biological property Gram-Negative Bacteria Drug Discovery medicine Side chain Antibacterial activity medicine.drug Antibacterial agent |
| Zdroj: | The Journal of Antibiotics. 45:500-504 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.45.500 |
| Popis: | A series of new penem compounds with a C-2 side chain consisting of a pyrrolidin-3'-ylthio group substituted with various aminocarbonyl groups at the C-5' position have been prepared. Antibacterial activity, stability to renal dehydropeptidase-I and affinity to penicillin-binding proteins of these compounds were investigated and compared with the corresponding carbapenem compounds. |
| Databáze: | OpenAIRE |
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