Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis
| Autor: | Michael J. DiMartino, Don E. Griswold, L. M. Hillegass, Nabil Hanna, Paul C. Meunier |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Immunology Arthritis Ibuprofen Arachidonic Acids Phenidone Pharmacology Piroxicam Dexamethasone Mice chemistry.chemical_compound Rheumatology medicine Animals Immunology and Allergy Pharmacology (medical) Serum amyloid P component Arachidonic Acid biology Eicosanoid metabolism Chemistry Imidazoles medicine.disease Serum Amyloid P-Component Thiazoles Eicosanoid Mice Inbred DBA biology.protein Pyrazoles Collagen Cyclooxygenase medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 31:1406-1412 |
| ISSN: | 1529-0131 0004-3591 |
| Popis: | The dual inhibitors of arachidonic acid metabolism, Smith KlineFrench (SKF) 86002, SKF 104351, and phenidone; the corticosteroid, dexamethasone; and the selective cyclooxygenase inhibitors, ibuprofen, indomethacin, naproxen, and piroxicam were evaluated for their antiarthritic potency in the murine, collagen-induced arthritis model. The ability of these compounds to alter the severity of arthritic lesions and to reduce serum levels of the acute-phase reactant, serum amyloid P component (SAP) were monitored. Serum concentrations of SAP were found to correlate strongly (r = 0.985) with disease severity at day 35 postimmunization. Treatment with SKF 86002, SKF 104351, phenidone, or dexamethasone significantly reduced disease severity, as judged by clinical score (55%, 72%, 41%, and 45% inhibition, respectively) and SAP levels (62%, 94%, 52%, and 94% inhibition, respectively) in arthritic mice. This profile of activity was not shared by the selective cyclooxygenase inhibitors, which did not uniformly inhibit disease activity by both parameters. The results suggest that dual inhibitors of 5-lipoxygenase and cyclooxygenase may prove more effective than selective cyclooxygenase inhibitors as anti-arthritic agents. |
| Databáze: | OpenAIRE |
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