Unnarmicins A and C, New Antibacterial Depsipeptides Produced by Marine Bacterium Photobacterium sp. MBIC06485
| Autor: | Atsuko Katsuta, Naoya Oku, Yoshikazu Shizuri, Kazutaka Kawabata, Kyoko Adachi |
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| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Antiparasitic medicine.drug_class Stereochemistry Stereoisomerism Microbial Sensitivity Tests Biology Microbiology chemistry.chemical_compound Biosynthesis Depsipeptides Drug Discovery medicine Pharmacology Depsipeptide Molecular Structure Photobacterium Nuclear magnetic resonance spectroscopy biology.organism_classification Anti-Bacterial Agents chemistry Fermentation Bacteria |
| Zdroj: | The Journal of Antibiotics. 61:11-17 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | Two new antibiotic depsipeptides, unnarmicins C (1) and A (2), were isolated from the fermentation broth of a marine bacterium, Photobacterium sp. strain MBIC06485. The structure of 1 was established by spectroscopic studies and chiral analyses of its chemical degradation/conversion products, and that of 2 by comparing its NMR, MS, and CD data with those of 1. Both compounds selectively inhibited the growth of two strains belonging to the genus Pseudovibrio, one of the most prevalent genera in the marine environments within the class Alphaproteobacteria. |
| Databáze: | OpenAIRE |
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