Effect of CRP and Kinetics of CRP in Prognosis of Nasopharyngeal Carcinoma
| Autor: | Yufeng Ren, Yu Zhou, Yong Chen, Qun Zhang, Sha-Sha He, Ruiwan Chen, Yujie Yuan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Poor prognosis lcsh:RC254-282 Gastroenterology C-reactive protein 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Stage (cooking) radiotherapy Original Research biology business.industry nasopharyngeal carcinoma Elevated crp lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Normal group 030104 developmental biology Oncology Nasopharyngeal carcinoma kinetics 030220 oncology & carcinogenesis biology.protein T-stage prognosis business After treatment |
| Zdroj: | Frontiers in Oncology, Vol 9 (2019) Frontiers in Oncology |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2019.00089 |
| Popis: | Baseline C-reactive protein (CRP) has been determined as a prognostic factor in nasopharyngeal carcinoma (NPC). This study was designed to further evaluate the impact of CRP kinetics on NPC patients. Thousand three hundred and seventy eight NPC patients from February 2001 to June 2011 were retrospectively reviewed. CRP were measured at beginning, middle, and the end of the treatment. The endpoints were overall survival (OS) and distant metastasis free survival (DMFS). Patients were divided into three groups according to baseline CRP and CRP kinetics: (1) continuously normal group: patients whose baseline CRP normal and never elevated, (2) ever-elevated group: patients whose CRP ever elevated regardless time points, (3) continuously elevated group: patients whose baseline CRP elevated and never normalized. Baseline CRP, CRP after treatment, and CRP kinetics were correlated with TNM stage, T stage, and N stage. Univariate and multivariate analysis identified that elevated baseline CRP and CRP after treatment had significant association with worse survival than normal CRP. Oppositely, elevated CRP during treatment was not associated with survival. Patients with continuously elevated CRP significantly had poor OS and DMFS (HR:2.610, 95%CI: 1.592–4.279, p < 0.001; HR:2.816, 95%CI: 1.486–5.302, p = 0.001, respectively). In multivariate analysis, CRP kinetics assessment is an independent prognostic factor for OS and DFMS in NPC patients (HR:2.512, 95%CI: 1.452–4.346, p = 0.001; HR:3.389, 95%CI: 1.734–6.625, p = 0.001, respectively). In conclusion, elevated CRP at baseline and after treatment are predictive factors of poor prognosis for NPC. The study of CRP kinetics shows that continuously elevated CRP during treatment might indicate an unfavorable prognosis for NPC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|