Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis
| Autor: | Hidemi Takeuchi, Hiromi Rakugi, Michihiro Okuyama, Yuka Okuyama, Shingo Kasahara, Hitoshi Sugiyama, Kentaro Wada, Yuki Kakio, Ken Sugimoto, Jun Wada, Haruhito A. Uchida, Ryoko Umebayashi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Disease 030204 cardiovascular system & hematology Logistic regression Risk Assessment Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Japan Renal Dialysis Risk Factors Internal medicine Diabetes mellitus Prevalence medicine Humans Diabetic Nephropathies Chronic hemodialysis 030212 general & internal medicine Risk factor Aged Retrospective Studies Kidney Frailty business.industry Incidence General Medicine Prognosis medicine.disease Cross-Sectional Studies medicine.anatomical_structure Kidney Failure Chronic Female Hemodialysis business Follow-Up Studies |
| Zdroj: | Geriatrics & Gerontology International. 18:1597-1602 |
| ISSN: | 1447-0594 1444-1586 |
| DOI: | 10.1111/ggi.13534 |
| Popis: | Aim Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients. Methods A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end-stage renal disease (DN group, n = 150) or not (Non-DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty. Results The prevalence of frailty in the DN group was significantly higher than that in the Non-DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non-frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty. Conclusions The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597-1602. |
| Databáze: | OpenAIRE |
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