ITPase activity modulates the severity of anaemia in HCV-related cirrhosis treated with ribavirin-containing interferon-free regimens
| Autor: | Maria Stanzione, Federica Calò, Carmine Minichini, Rosa Zampino, Mario Starace, Luca Rinaldi, Nicola Coppola, Salvatore Martini, Pietro Filippini, Stefania De Pascalis, Giovanni Battista Gaeta, Antonio Riccardo Buonomo, Ivan Gentile, Giorgio de Stefano, Alessandro Federico, Marcello Persico, Giovanni Di Caprio, Vincenzo Messina, G. Stornaiuolo, Guglielmo Borgia, Tiziana Ascione, Vincenzo Sangiovanni |
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| Přispěvatelé: | Coppola, Nicola, De Pascalis, S, Messina, V, Di Caprio, G, Martini, Saturnino, de Stefano, G, Starace, M, Stornaiuolo, G, Stanzione, M, Ascione, T, Minichini, C, Sangiovanni, V, Zampino, Rosa, Calã², F, Rinaldi, L, Persico, M, Federico, Alessandro, Buonomo, Ar, Borgia, G, Gaeta, Giovanni Battista, Filippini, Pietro, Gentile, I., De Pascalis, Stefania, Messina, Vincenzo, Di Caprio, Giovanni, Martini, Salvatore, de Stefano, Giorgio, Starace, Mario, Stornaiuolo, Gianfranca, Stanzione, Maria, Ascione, Tiziana, Minichini, Carmine, Sangiovanni, Vincenzo, Calò, Federica, Rinaldi, Luca, Persico, Marcello, Buonomo, ANTONIO RICCARDO, Borgia, Guglielmo, Gentile, Ivan |
| Rok vydání: | 2017 |
| Předmět: |
Liver Cirrhosis
Male Cirrhosis 01 natural sciences Gastroenterology Severity of Illness Index ITPase activity chemistry.chemical_compound 0302 clinical medicine Gene Frequency Risk Factors Odds Ratio Pharmacology (medical) Chronic Pyrophosphatases Anemia Single Nucleotide Middle Aged Hepatitis C Infectious Diseases Combination 030211 gastroenterology & hepatology Drug Therapy Combination Female Disease Susceptibility INOSINE TRIPHOSPHATASE medicine.medical_specialty Aged Alleles Antiviral Agents Enzyme Activation Genotype Hepatitis C Chronic Humans Polymorphism Single Nucleotide Ribavirin 010402 general chemistry 03 medical and health sciences Drug Therapy Internal medicine medicine Polymorphism Pharmacology business.industry Interferon free medicine.disease 0104 chemical sciences chemistry business |
| Popis: | Background To investigate the association between inosine triphosphatase (ITPase) activity and the degree of anaemia occurring during direct-acting antiviral (DAA)/ribavirin (RBV)-based therapy in patients with cirrhosis. Methods In a multicentre, prospective study 227 patients with HCV-related cirrhosis treated with DAA and RBV were enrolled. All patients were screened for the rs1127354 and rs7270101 ITPA single nucleotide polymorphisms using direct sequencing. Results 150 (66.1%) patients had normal (100%) ITPase activity, 48 (21.1%) had moderate (60%) activity and 29 (12.8%) minimal (≤30%) activity. The ITPase activity significantly influenced the haemoglobin concentration: at day 15 it was -1.248 (sd ±0.978) in the 150 patients with an ITPase activity of 100% and -0.616 (±0.862) in the 77 patients with an ITPase activity less than 100% ( P Conclusions This study suggests that the polymorphisms in the ITPA gene influence the severity of anaemia during the first month of a DAA/RBV-based treatment in HCV-related cirrhosis. |
| Databáze: | OpenAIRE |
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