Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy
| Autor: | Gabutti, Giovanni, Bergamini, M., Bonanni, P., Signorino, Guido, Fenoglio, D., Giammanco, A., Sindoni, L., Zotti, C., Boddi, V., Bamfi, F., Severini, R., Bechini, A., Boccalini, S., Crovari, P., Ditommaso, S., Gentile, M., Lanci, G., Durando, P., Sticchi, L., Renzoni, A., Fuliano, P., Tripodi, G., Cavallaro, A., Pesavento, G., Silei Secchini, T., Innocenti, B., Squeri, R., La Fauci, V., Calimeri, S., Lo Giudice, D., De Donno, A., Quattrocchi, M., Sanapo, F., Pasanisi, G. C., Taormina, S., Bonura, C., Calã , C., Ferrera, A. |
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| Přispěvatelé: | Gabutti, G, Bergamini, M, Bonanni, P, Guido, Marcello, Fenoglio, D, Giammanco, A, Sindoni, L, Zotti, C, Boddi, V, Bamfi, F, Severini, R, Bechini, A, Boccalini, S, Crovari, P, AND COLLABORATIVE GROUP FOR STUDY OF, Pertussis, GABUTTI G, BERGAMINI M, BONANNI P, GUIDO M, FENOGLIO D, GIAMMANCO A, SINDONI L, ZOTTI C, BODDI V, BAMFI F, SEVERINI R, BECHINI A, BOCCALINI S, CROVARI P, DITOMMASO S, GENTILE M, LANCI G, DURANDO P, STICCHI L, RENZONI A, FULIANO P, TRIPODI G, CAVALLARO A, PESAVENTO G, SILEI SECCHINI T, INNOCENTI B, SQUERI R, LA FAUCI V, CALIMERI S, LO GIUDICE D, DE DONNO A, QUATTROCCHI M, SANAPO F, PASANISI GC, TAORMINA S, BONURA C, CALA C, FERRERA A |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Settore MED/07 - Microbiologia E Microbiologia Clinica Cellular immunity Bordetella pertussis Epidemiology Whooping Cough Seroepidemiologic Studies 80 and over Lymphocytes Aged 80 and over education.field_of_study biology adult Bacterial Middle Aged Original Papers Antibodies Bacterial senior Infectious Diseases B. pertussis Humoral and cell-mediated immunity ELISA Italy Female Antibody Adult medicine.medical_specialty Bordetella pertussi Adolescent Aged Antitoxins Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G Population Antibodies NO Immunity medicine education immunità cellulo mediata business.industry biology.organism_classification adolescent Humoral immunity Immunology Etiology biology.protein immunità umorale business |
| Popis: | SUMMARYHumoral and cell-mediated immunity (CMI) againstB. pertussiswas assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99·1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [⩾2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6·2% samples recorded titres ⩾100 EU/ml. CMI was positive [stimulation index (SI) ⩾5] against PT in 39·0% of all samples. This study suggests thatB. pertussiscontinues to circulate in age groups that have been previously considered to be uninvolved in the circulation of this pathogen and that adolescent and adult pertussis boosters may be of value in these populations. Nevertheless, over the last 10 years, large increases in vaccination coverage rates have contributed to reduce the spread of the aetiological agent, especially in the immunized population. |
| Databáze: | OpenAIRE |
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