Tocilizumab, a potent interleukin-6 receptor inhibitor, decreases bone resorption and increases the rate of bacterial infection after tooth extraction in rats
| Autor: | Maria Elisa Quezado Lima Verde, Fabrício Bitu Sousa, Ana Paula Negreiros Nunes Alves, Maria Imaculada de Queiroz Rodrigues, Paulo Goberlânio de Barros Silva, Mário Rogério Lima Mota, Joyce Ohana de Lima Martins, Antonio Ernando Carlos Ferreira Junior |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Molar Oral medicine.medical_specialty medicine.medical_treatment Alveolar Bone Loss Bone healing Neutropenia Antibodies Monoclonal Humanized Gastroenterology Bone resorption Article 03 medical and health sciences 0302 clinical medicine Osteoclast Internal medicine medicine Animals Bone Resorption Rats Wistar Saline Leukopenia biology business.industry Interleukin-6 Bacterial Infections 030206 dentistry medicine.disease Receptors Interleukin-6 Focal Infection Rats medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Myeloperoxidase Tooth Extraction biology.protein Dental Surgery Oral Surgery medicine.symptom business |
| Zdroj: | Journal of Oral and Maxillofacial Surgery |
| ISSN: | 1531-5053 0278-2391 |
| Popis: | Purpose Our objective was to evaluate the influence of pre-treatment with tocilizumab (TCZ) in bone healing after tooth extraction in rats. Methods Wistar male rats were equally divided into sham (i.e., non-operated), saline (both treated with 0.1 ml/kg saline), and six TCZ groups treated with 1, 2, 4, 8, 16, and 32 mg/kg TCZ (TCZ1 to TCZ32, respectively). Twenty-four hours after administration of vehicle or TCZ, exodontia of the first lower left molar was performed, and the animals were euthanized three days later for hematological analysis and organ (liver, spleen, and kidney mass indexes, and histological evaluation), gingiva (myeloperoxidase [MPO] assay), and mandible (radiographic, histomorphometric analysis, and IL-6 immunostaining) evaluation. Analysis of variance/Bonferroni test (statistical significance, p |
| Databáze: | OpenAIRE |
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