Intestinal calcium and lead absorption: Effects of dietary lead and calcium
| Autor: | Curtis S. Fullmer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Calbindins
medicine.medical_specialty Time Factors Fowl Administration Oral chemistry.chemical_element Absorption (skin) Calcium Biochemistry Intestinal absorption S100 Calcium Binding Protein G Oral administration Internal medicine medicine Animals Ingestion Toxicokinetics Intestinal Mucosa General Environmental Science biology Phosphorus biology.organism_classification Calcium Dietary Intestines Endocrinology Intestinal Absorption Lead chemistry Toxicity Chickens |
| Zdroj: | Environmental Research. 54:159-169 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/s0013-9351(05)80098-2 |
| Popis: | The combined effects of dietary calcium (Ca) and lead (Pb) status on intestinal Ca and Pb absorption and related parameters were investigated in young growing chicks. Dietary Pb intake resulted in two remarkable, apparently independent and essentially opposite effects on intestinal Ca and Pb absorption, depending on dietary Ca and Pb levels and duration of treatment. The initial response (1 week) to Ca deficiency was stimulated Ca absorption and calbindin-D level, regardless of dietary Pb intake. The later response (2 weeks) was a reversal, by Pb, of the early phase stimulation. Intestinal Pb absorption was similarly enhanced by Ca deficiency initially, and this response was also inhibited by prolonged dietary Pb intake. Ingestion of Pb by chicks fed adequate Ca resulted in generally elevated intestinal Ca absorption and calbindin-D levels after both 1 and 2 weeks. Intestinal Pb absorption was also increased in the adequate Ca situation, but only after 2 weeks at the lower levels of dietary Pb. The results underscore the complicated nature of Pb-Ca interactions and demonstrate the importance of thorough characterization of the animal model system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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