Hb Phnom Penh Showing Falsely High or Reasonable HbA1c Values Depending on the Type of High-performance Liquid Chromatography System
| Autor: | Rika Naruse, Takafumi Tsuchiya, Toshihiko Inukai, Mototaka Yamauchi, Kenji Hara, Koshi Hashimoto, Masafumi Koga, Kohzo Takebayashi, Hiroyuki Shinozaki, Tatsuhiko Suzuki |
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| Rok vydání: | 2020 |
| Předmět: |
HbA1c
high performance liquid chromatography Hemoglobins Abnormal Case Report Reference range 030204 cardiovascular system & hematology Sensitivity and Specificity High-performance liquid chromatography 03 medical and health sciences 0302 clinical medicine Hplc assay Internal Medicine Humans Medicine Oral glucose tolerance Chromatography High Pressure Liquid Glycated Hemoglobin Immunoassay Normal glucose tolerance Chromatography medicine.diagnostic_test business.industry variant hemoglobin General Medicine Glucose Tolerance Test Middle Aged Phnom penh Hb Phnom Penh Female 030211 gastroenterology & hepatology business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.3306-19 |
| Popis: | We herein report a 50-year-old Chinese woman with Hb Phnom Penh (α117Phe-Ile-α118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high. |
| Databáze: | OpenAIRE |
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