The effect of inhaled corticosteroids in the outcomes of community-acquired pneumonia: ICCAP study (TURKCAP Database)
| Autor: | Armagan Hazar, Fatma Tokgöz, Aysin Sakar Coskun, Sakine Nazik Bahçecioğlu, Burcu Celenk, Feride Durmaz, Dilek Yapar, Ayse Baha, Nur Aksakal, Seda Salman, Canan Gunduz, Oguz Kilinc, Sezai Tasbakan, Aykut Cilli, Nurdan Kokturk, Abdullah Sayiner |
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| Přispěvatelé: | Ege Üniversitesi, Department of Pulmonary Diseases, Akcicek State Hospital, Kyrenia, Cyprus, Department of Pulmonary Diseases, Gazi University Faculty of Medicine, Ankara, Turkey, Department of Allergy Immunology and Pulmonary Diseases, Erciyes University Faculty of Medicine, Kayseri, Turkey, Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey, Department of Pulmonary Diseases, Ege University Faculty of Medicine, Izmir, Turkey, Department of Pulmonary Diseases, Celal Bayar University Faculty of Medicine, Manisa, Turkey, Department of Pulmonary Diseases, Sureyyapasa Education and Research Hospital, Istanbul, Turkey, Department of Pulmonary Diseases, Akdeniz University Faculty of Medicine, Antalya, Turkey, Department of Pulmonary Diseases, Antalya Atatürk Training and Research Hospital, Antalya, Turkey, Department of Pulmonary Diseases, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, Department of Chest Diseases, Canakkale State Hospital, Canakkale, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Turkey Community-acquired pneumonia Inhaled corticosteroids computer.software_genre 03 medical and health sciences 0302 clinical medicine Risk Factors Administration Inhalation medicine Immunology and Allergy Humans COPD 030212 general & internal medicine Hospital Mortality Lung cancer Glucocorticoids Genetics (clinical) Asthma Aged Retrospective Studies Database treatment business.industry Pneumonia Middle Aged medicine.disease Multivariate logistic regression model Community-Acquired Infections Hospitalization Survival Rate Cross-Sectional Studies Logistic Models Treatment Outcome 030228 respiratory system Crackles Female prognosis medicine.symptom business computer |
| Popis: | Objective: We aimed to investigate the effect of inhaled corticosteroids (ICS) in the outcomes of community-acquired pneumonia (CAP), as well as to determine if ICS usage is exist among the risk factors for mortality in those patients. Materials and Methods: In this retrospective cross-sectional multicentre study, 1069 hospitalised CAP patients were investigated using CAP Database of Turkish Thoracic Society (TURKCAP Database). The patients were divided into two groups, depending on their ICS use. The data were analysed by appropriate statistical methods. Results: 172 (75.8%) of the 227 patients who were on ICS had COPD and 37 (16.3%) had asthma. There were fewer patients with fever among ICS-users compared to non-ICS users (P = 0.013), and less muscle pain (P = 0.015) and fewer GIS symptoms (P = 0.022). No statistically significant difference was found between ICS use/ type of ICS and the duration of hospitalisation (P = 0.286). The multivariate regression analysis showed that patients using ICS had lower body temperature and, less crackles/bronchial sound. In the multivariate logistic regression model lung cancer (OR: 6.75), glucose (OR: 1.01) and CURB-65 (OR: 1.72) were significantly associated with mortality in the CAP patients. ICS usage were not found to be associated with mortality. Conclusion: The use of ICS by the patients with CAP admitted to the hospital is not independently related with any radiological pattern, hospitalisation duration and mortality. ICS usage may diminish fever response and may suppress the findings of crackles and/or bronchial sounds. This needs further confirmation. © 2020 John Wiley & Sons Ltd |
| Databáze: | OpenAIRE |
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