Preliminary Observations on the Effect of Amitriptyline Treatment in Preventing Syncope Recurrence in Patients with Vasovagel Syncope
| Autor: | Gulcan Abali, Hilmi Ozkutlu, Basri Amasyali, Ali Oto, Uğur Kocabaş, Nasih Nazli, Ergun Baris Kaya, Kudret Aytemir, Lale Tokgozoglu, Giray Kabakci, Sedat Kose |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Amitriptyline Administration Oral Tricyclic antidepressant Tilt table test Tilt-Table Test Physiology (medical) Internal medicine Secondary Prevention Syncope Vasovagal medicine Anticholinergic Humans Vasovagal syncope Presyncope Adrenergic Uptake Inhibitors medicine.diagnostic_test biology business.industry Syncope (genus) Original Articles General Medicine medicine.disease biology.organism_classification Treatment Outcome Anesthesia Anxiety Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Annals of Noninvasive Electrocardiology. 12:153-157 |
| ISSN: | 1542-474X 1082-720X |
| DOI: | 10.1111/j.1542-474x.2007.00154.x |
| Popis: | Purpose: Vasovagal syncope is a common and challenging problem that may result in injury and causes susbstantial anxiety among patients and their relatives. However, treatment of vasovagal syncope with standard pharmacologic approaches is not satisfactory. The aim of this study is to investigate the effect of amitriptyline, a tricyclic antidepressant drug, by using its anticholinergic effects in preventing syncopal episodes in patients with vasovagal syncope. Methods: In this study, 74 patients (mean age 24 ± 1.9 years, 26 male) with a history of recurrent syncope and baseline positive head-up tilt table test (syncope or presyncope) were included. Oral amitriptyline treatment was given to all patients, with a starting dose of 10 mg once a day. Head-up tilt table test was performed in all patients 4 weeks after the treatment started. Patients were followed up clinically for 6 months. Results: After 4 weeks, during head-up tilt table test in 69 patients (93%), syncope or presyncope was not seen and test was assumed as negative. At the end of the 6th month, 67 patients (91%) were free of symptoms. Only two patients (0.3%) did not tolerate amitriptyline due to side effects. Conclusions: Oral amitriptyline can be used in the prevention of recurrent episodes of vasovagal syncope safely. However, randomized controlled studies are essential to assess the real effectiveness of this therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|