Enantioselective Fluoroamination: 1,4-Addition to Conjugated Dienes Using Anionic Phase-Transfer Catalysis

Autor:	F. Dean Toste, Yi-Ming Wang, Hunter P. Shunatona, Vivek Rauniyar, Natalja Früh
Rok vydání:	2013
Předmět:	Enantioselective synthesis General Medicine General Chemistry Conjugated system Catalysis chemistry.chemical_compound chemistry Phase (matter) Reagent Organic chemistry Amine gas treating Isoquinoline Selectfluor
Zdroj:	Angewandte Chemie International Edition. 52:7724-7727
ISSN:	1433-7851
DOI:	10.1002/anie.201302002
Popis:	Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ad99066701f649e701317de8661cd0 https://doi.org/10.1002/anie.201302002 Zobrazit plný text záznamu Plný text