Pseudomyxoma peritonei: a French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy
| Autor: | François Quenet, Baudouin Mansvelt, Lucas Sideris, Dominique Elias, Olivier Glehen, F. N. Gilly, J.M. Bereder, Gérard Lorimier |
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| Přispěvatelé: | Département de chirurgie générale [Gustave Roussy], Institut Gustave Roussy ( IGR ), Department of Oncologic Surgery, Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Center Val d'Aurel, Center Hospitalo-Universitaire, Hopital Jolimont, Center Paul Papin |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Hyperthermia medicine.medical_specialty Mitomycin intraperitoneal chemotherapy peritoneal pseudomyxoma [ SDV.CAN ] Life Sciences [q-bio]/Cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans Pseudomyxoma peritonei cytoreductive surgery Infusions Parenteral Peritoneal Neoplasms Survival analysis Aged Retrospective Studies business.industry Retrospective cohort study Intraperitoneal chemotherapy Hyperthermia Induced General Medicine Perioperative Middle Aged Pseudomyxoma Peritonei medicine.disease hyperthermia Survival Analysis Surgery Treatment Outcome Oncology Female Hyperthermic intraperitoneal chemotherapy Fluorouracil France prognosis Cytoreductive surgery business |
| Zdroj: | EJSO-European Journal of Surgical Oncology EJSO-European Journal of Surgical Oncology, WB Saunders, 2010, 36 (5), pp.456. 〈10.1016/j.ejso.2010.01.006〉 |
| ISSN: | 0748-7983 |
| Popis: | Objective To analyze a large series of patients with pseudomyxoma peritonei (PMP) treated with cytoreductive surgery associated with perioperative intraperitoneal chemotherapy (PIC) in 18 French-speaking centers. Patients and methods From March 1993 to December 2007, 301 patients with diffuse PMP were treated by cytoreductive surgery with PIC. Complete cytoreductive surgery was achieved in 219 patients (73%), and hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 255 (85%), mainly during the latter period of the study. Results Postoperative mortality and morbidity were 4.4% and 40%, respectively. The mean follow-up was 88 months. The 5-year overall and disease-free survival rates were 73% and 56%, respectively. The multivariate analysis identified 5 prognostic factors: the extent of peritoneal seeding ( p = 0.004), the center ( p = 0.0004), the pathologic grade ( p = 0.03), gender ( p = 0.02), and the use of HIPEC ( p = 0.04). When only the 206 patients with complete cytoreductive surgery were considered, the extent of peritoneal seeding was the only significant prognostic factor ( p = 0.004). Conclusion This large multicentric retrospective study confirms that cytoreductive surgery combined with PIC (with the use of hyperthermia) should be considered as the gold standard treatment of PMP and should be performed in specialized centers. It underlines the prognostic impact of the extent of peritoneal seeding, especially in patients treated by complete cytoreductive surgery. This prognostic impact appears to be greater than that of the pathologic grade. |
| Databáze: | OpenAIRE |
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