Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
| Autor: | Richard Rivera, Randall S. Johnson, Jeanette Quan, Cornelis Murre, Carol P. Johns |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Cellular differentiation Receptors Antigen T-Cell alpha-beta T-Lymphocytes Immunology Gene Expression Mice Transgenic Thymus Gland Major histocompatibility complex Negative selection Mice hemic and lymphatic diseases Gene expression Immunology and Allergy Animals Transcription factor Gene Genetics Mice Knockout B-Lymphocytes Mice Inbred BALB C biology Basic helix-loop-helix Helix-Loop-Helix Motifs Histocompatibility Antigens Class I Histocompatibility Antigens Class II Cell Differentiation Neoplasm Proteins Mice Inbred C57BL Thymocyte Receptors Antigen Infectious Diseases biology.protein Female Inhibitor of Differentiation Proteins Transcription Factors |
| Zdroj: | Karolinska Institutet |
| ISSN: | 1074-7613 |
| Popis: | E2A, HEB, E2–2, and daughterless are basic helix-loop-helix (bHLH) proteins that play key roles in multiple developmental pathways. The DNA binding activity of E2A, HEB, and E2-2 is regulated by a distinct class of inhibitor HLH proteins, the Id gene products. Here, we show that Id3 is required for major histocompatability (MHC) class I– and class II–restricted thymocyte positive selection. Additionally, H-Y TCR–mediated negative selection is severely perturbed in Id3 null mutant mice. Finally, we show that E2A and Id3 interact genetically to regulate thymocyte development. These observations identify the HLH inhibitory protein Id3 as an essential component required for proper thymocyte maturation. |
| Databáze: | OpenAIRE |
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