Two-step Intensity-modulated Radiation Therapy for Oropharyngeal Cancer: Initial Clinical Experience and Validation of Clinical Staging
| Autor: | Shuichi Kanamori, H. Tatebe, Hisato Kawakami, Mutsukazu Kitano, Hiroshi Doi, Kiyoshi Nakamatsu, Kazuki Ishikawa, Yasumasa Nishimura, Toru Shibata, Masaki Yokokawa |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Two step Planning target volume 03 medical and health sciences 0302 clinical medicine otorhinolaryngologic diseases medicine Overall survival Humans Human papillomavirus Aged Retrospective Studies Aged 80 and over business.industry Radiotherapy Planning Computer-Assisted Cancer Radiotherapy Dosage General Medicine Middle Aged Intensity-modulated radiation therapy Prognosis medicine.disease Survival Rate Radiation therapy Oropharyngeal Neoplasms stomatognathic diseases Oncology 030220 oncology & carcinogenesis Total dose Carcinoma Squamous Cell Female Radiotherapy Intensity-Modulated Radiology Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Anticancer Research. 38 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.12312 |
| Popis: | Aim To evaluate the clinical results of two-step intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer. Patients and methods Eighty patients were treated with two-step IMRT between 2002 and 2014. Whole-neck radiotherapy (44.0-50.0 Gy/22-25 fractions) was delivered by IMRT, followed by boost IMRT to the high-risk clinical target volume (total dose of 70.0 Gy/35 fractions). Forty-seven patients received concurrent chemotherapy. Immunohistochemistry for human papillomavirus type 16 (HPV/p16) was performed for 64 patients. Results The 5-year overall survival and locoregional control rates for stage I, II, III, and IVA-B disease were 80.0%, 75.0%, 78.0%, and 64.0% and 100.0%, 75.0%, 92.0%, and 82.0%, respectively. Overall survival was significantly higher in HPV/p16-positive patients than in HPV/p16-negative patients (p=0.01). Xerostomia of grade 2 or more was noted in 10 patients. Conclusion Favourable overall survival and locoregional control rates with excellent salivary preservation were obtained using the two-step IMRT method for oropharyngeal cancer. |
| Databáze: | OpenAIRE |
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