Effector-Triggered Self-Replication in Coupled Subsystems
| Autor: | Dávid Komáromy, Gaël Schaeffer, Sijbren Otto, Ivana Marić, Meniz Tezcan |
|---|---|
| Přispěvatelé: | Synthetic Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Cell division
010405 organic chemistry Effector Chemistry Distributed computing DYNAMIC COMBINATORIAL LIBRARIES Nanotechnology General Medicine General Chemistry 010402 general chemistry 01 natural sciences SYSTEMS CHEMISTRY Catalysis Replication (computing) EVOLUTION 0104 chemical sciences Living systems NETWORKS EMERGENCE Coupling (computer programming) Self-replication Block (programming) CELLS Dynamic combinatorial chemistry Journal Article |
| Zdroj: | Angewandte Chemie-International Edition, 56(46), 14658-14662. WILEY-V C H VERLAG GMBH |
| ISSN: | 1521-3773 |
| Popis: | In living systems processes like genome duplication and cell division are carefully synchronized through subsystem coupling. If we are to create life de novo, similar control over essential processes such as self-replication need to be developed. Here we report that coupling two dynamic combinatorial subsystems, featuring two separate building blocks, enables effector-mediated control over self-replication. The subsystem based on the first building block shows only self-replication, whereas that based on the second one is solely responsive toward a specific external effector molecule. Mixing the subsystems arrests replication until the effector molecule is added, resulting in the formation of a host-effector complex and the liberation of the building block that subsequently engages in self-replication. The onset, rate and extent of self-replication is controlled by the amount of effector present. |
| Databáze: | OpenAIRE |
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