Brain Mechanisms of COVID-19-Sleep Disorders

Autor: Elena Saranceva, Dan Zhu, Jürgen Kurths, Maria Klimova, Vasily Ageev, Tingting Yu, Oxana Semyachkina-Glushkovskaya, Thomas Penzel, Aysel Mamedova, Valeria Vinnik
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6917, p 6917 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms22136917
Popis: 2020 and 2021 have been unprecedented years due to the rapid spread of the modified severe acute respiratory syndrome coronavirus around the world. The coronavirus disease 2019 (COVID-19) causes atypical infiltrated pneumonia with many neurological symptoms, and major sleep changes. The exposure of people to stress, such as social confinement and changes in daily routines, is accompanied by various sleep disturbances, known as ‘coronasomnia’ phenomenon. Sleep disorders induce neuroinflammation, which promotes the blood–brain barrier (BBB) disruption and entry of antigens and inflammatory factors into the brain. Here, we review findings and trends in sleep research in 2020–2021, demonstrating how COVID-19 and sleep disorders can induce BBB leakage via neuroinflammation, which might contribute to the ‘coronasomnia’ phenomenon. The new studies suggest that the control of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for the prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of BBB leakage, and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption. Russian Science Foundation Russian Foundation for Basic Research Ministry of Science and Higher Education of the Russian Federation Foundation for Innovative Research Groups of the National Natural Science Foundation of China
Databáze: OpenAIRE
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