The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis
| Autor: | Shi Chen, Shiyi Tan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death autophagy QH301-705.5 Review Catalysis Inorganic Chemistry Pathogenesis 03 medical and health sciences 0302 clinical medicine Silicosis silicosis Medicine Humans Biology (General) Physical and Theoretical Chemistry Regulated Cell Death QD1-999 Molecular Biology programmed cell death Spectroscopy business.industry pyroptosis Organic Chemistry Autophagy Pyroptosis apoptosis General Medicine medicine.disease Computer Science Applications Chemistry Crosstalk (biology) 030104 developmental biology Apoptosis 030220 oncology & carcinogenesis Cancer research Disease Progression Signal transduction business Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 8110, p 8110 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by chronic exposure to silica dust. In this review, we have proposed that programmed cell death (PCD), including autophagy, apoptosis, and pyroptosis, is closely associated with silicosis progression. Furthermore, some autophagy, apoptosis, or pyroptosis-related signaling pathways or regulatory proteins have also been summarized to contribute greatly to the formation and development of silicosis. In addition, silicosis pathogenesis depends on the crosstalk among these three ways of PCD to a certain extent. In summary, more profound research on these mechanisms and effects may be expected to become promising targets for intervention or therapeutic methods of silicosis in the future. |
| Databáze: | OpenAIRE |
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