Effects of genetic background on responses to superovulation in Japanese Black cattle
Autor: | Toshiro Takedomi, Satoru Moriyasu, Akira Naito, Takashi Fujii, Soichi Kageyama, Hiroki Hirayama, Hitomi Sakai, Masahito Sugimoto |
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Rok vydání: | 2019 |
Předmět: |
Anti-Mullerian Hormone
endocrine system Genotype 040301 veterinary sciences media_common.quotation_subject Biology Japanese Black cattle 0403 veterinary science Andrology 03 medical and health sciences bloodline FSHR Polymorphism (computer science) Follicular phase GRIA1 Animals Receptors AMPA Allele Ovulation 030304 developmental biology media_common superovulation 0303 health sciences Full Paper General Veterinary 04 agricultural and veterinary sciences Antral follicle Genotype frequency Receptors FSH Cattle Female Theriogenology Genetic Background Hormone |
Zdroj: | The Journal of Veterinary Medical Science |
ISSN: | 1347-7439 0916-7250 |
Popis: | We investigated the effects of genetic background on the responses to superovulation in Japanese Black cattle. The genotype frequencies of GRIA1 and FSHR relating to ovulation and follicular development in each of the major bloodlines—Tajiri, Fujiyoshi, and Kedaka—were analyzed. The Tajiri line had the lowest frequency of G allele homozygosity of c.710A>G in GRIA1 among the three bloodlines, and deviation from Hardy–Weinberg equilibrium was detected. Genotype frequencies of c.337C>G, c.871A>G, and c.1973C>G in FSHR were in Hardy–Weinberg equilibrium in all bloodlines. The results of generalized linear mixed-model analyses showed that farm, levels of plasma anti-Müllerian hormone (AMH) concentration, age in months, repeated superovulation, c.337C>G in FSHR, and bloodlines had significant effects on the responses to superovulation. The number of transferable embryos in the group heterozygous for c.337C>G in FSHR was significantly higher than that in the group homozygous for the C allele. The Kedaka line showed a significantly higher number of ova/embryos, fertilized embryos, and transferable embryos than the Tajiri and Fujiyoshi lines. The concentration of circulating AMH is a useful endocrine marker for antral follicle counts. This study revealed the effects of genetic background on the responses to superovulation using levels of plasma AMH concentration as a covariate. The prominent effect of genetic background on superovulation in the Kedaka line requires additional studies to confirm the genomic regions and polymorphisms that are involved in the trait. |
Databáze: | OpenAIRE |
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